NFL Week 16 (‘25) Best Odds Compared (Sportsbook)

Week 16 NFL Odds - Novig vs DraftKings

Week 16 has arrived. Below is a full look at this week’s NFL odds across spreads, totals, and moneylines, along with spots where Novig is beating sportsbooks like DraftKings so you can see how better pricing can make a real difference over time.

If you want the strongest possible number on every NFL side and total, the platform you use matters just as much as the pick itself. Instead of paying the built in sportsbook margin, Novig lets you ditch the vig and trade at sharper prices. 

Here are the NFL odds for all Week 16 matchups.

NFL Spreads Week 16

The largest spread on the Week 16 slate appears in one game. Raiders vs Texans is set at 14.5 points, making Houston the biggest favorite of the week. Bills vs Browns follows closely behind with Buffalo favored by 10.5 points.

The smallest spread of the week is 1.5 points and seen in the Rams vs Seahawks, Chargers vs Cowboys, and Packers vs Bears matchups.

NFL Totals Week 16

The Steelers vs Lions matchup is projected to be the highest scoring game of Week 16, with the total set at 51.5 points. 

The lowest over under on the Week 16 slate belongs to the Raiders vs Texans matchup, with the total set at 37.5 points. Chiefs vs Titans also sits near the bottom, pointing to a more defense focused game script.

NFL Moneylines Week 16

The largest moneyline favorites this week are the Texans, Bills, and Eagles. All three teams enter their matchups as heavy favorites and carry very substantial negative moneylines.

NFL Lines and Line Shopping Week 16

Odds are provided from DraftKings Sportsbook and Novig Prediction Market and updated as of Thursday, Dec. 18th at 11:00 a.m. ET.

This overview compares Week 16 lines and odds across FanDuel and Novig to highlight where the best prices can be found.

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Thursday, Dec 18th

1. LA Rams vs SEA Seahawks

Seattle Seahawks are a slight favorite in their Week 16 matchup against the Los Angeles Rams. Price is much more favorable on the Novig (right) platform compared to FanDuel (left). 

Saturday, Dec 20th

2. PHI Eagles vs WAS Commanders

Philadelphia Eagles are a solid favorite in their Week 16 matchup against the Washington Commanders. Price is much more favorable on the Novig (right) platform compared to FanDuel (left). 

3. GB Packers vs CHI Bears

Green Bay Packers are a slight favorite in their Week 16 matchup against the Chicago Bears. Price is much more favorable on the Novig (right) platform compared to FanDuel (left). 

Sunday, Dec 21st

4. TB Buccaneers vs CAR Panthers

Tampa Bay Buccaneers are a slight favorite in their Week 16 matchup against the Carolina Panthers. Price is much more favorable on the Novig (right) platform compared to FanDuel (left). 

5. BUF Bills vs CLE Browns

Buffalo Bills are a heavy favorite in their Week 16 matchup against the Cleveland Browns. Price is much more favorable on the Novig (right) platform compared to FanDuel (left). 

6. LA Chargers vs DAL Cowboys

Dallas Cowboys are a slight favorite in their Week 16 matchup against the Los Angeles Chargers. Price is much more favorable on the Novig (right) platform compared to FanDuel (left). 

7. NY Jets vs NO Saints

New Orleans Saints are a solid favorite in their Week 16 matchup against the New York Jets. Price is much more favorable on the Novig (right) platform compared to FanDuel (left). 

8. MIN Vikings vs NY Giants

Minnesota Vikings are a slight favorite in their Week 16 matchup against the New York Giants. Price is much more favorable on the Novig (right) platform compared to FanDuel (left). 

9. KC Chiefs vs TEN Titans

Kansas City Chiefs are a solid favorite in their Week 16 matchup against the Tennessee Titans. Price is much more favorable on the Novig (right) platform compared to FanDuel (left). 

10. CIN Bengals vs MIA Dolphins

Cincinnati Bengals are a solid favorite in their Week 16 matchup against the Miami Dolphins. Price is much more favorable on the Novig (right) platform compared to FanDuel (left). 

11. ATL Falcons vs ARI Cardinals

Atlanta Falcons are a slight favorite in their Week 16 matchup against the Arizona Cardinals. Price is much more favorable on the Novig (right) platform compared to FanDuel (left). 

12. JAX Jaguars vs DEN Broncos

Denver Broncos are a slight favorite in their Week 16 matchup against the Jacksonville Jaguars. Price is much more favorable on the Novig (right) platform compared to FanDuel (left). 

13. PIT Steelers vs DET Lions

Detroit Lions are a solid favorite in their Week 16 matchup against the Pittsburgh Steelers. Price is much more favorable on the Novig (right) platform compared to FanDuel (left). 

14. LV Raiders vs HOU Texans

Houston Texans are a heavy favorite in their Week 16 matchup against the Las Vegas Raiders. Price is much more favorable on the Novig (right) platform compared to FanDuel (left). 

15. NE Patriots vs BAL Ravens

Baltimore Ravens are a slight favorite in their Week 16 matchup against the New England Patriots. Price is much more favorable on the Novig (right) platform compared to FanDuel (left). 

Monday, Dec 22nd

16. SF 49ers vs IND Colts

San Francisco 49ers are a heavy favorite in their Week 16 matchup against the Indianapolis Colts. Price is much more favorable on the Novig (right) platform compared to FanDuel (left).